fusidic acid free acid
fusidic acid free acid
CAS: 6990-06-3
Molecular Formula: C31H48O6
fusidic acid free acid - Names and Identifiers
fusidic acid free acid - Physico-chemical Properties
| Molecular Formula | C31H48O6 |
| Molar Mass | 516.72 |
| Density | 1.0389 (rough estimate) |
| Melting Point | 190-192°C |
| Boling Point | 521.49°C (rough estimate) |
| Specific Rotation(α) | D20 -9° (chloroform) |
| Flash Point | 197.6°C |
| Water Solubility | 2.376-525000μg/L at 25℃ |
| Solubility | Soluble in alcohol (1:5), chloroform (1:4), ether (1:60), and ethanol (50 mg/ml). Insolu |
| Vapor Presure | 0-0Pa at 25℃ |
| Appearance | neat |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['204nm(H2O)(lit.)'] |
| Merck | 14,4317 |
| pKa | pK: 5.35 in water |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Hygroscopic |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.4890 (estimate) |
| MDL | MFCD00865135 |
fusidic acid free acid - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | RC1350000 |
| HS Code | 29419000 |
| Toxicity | LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen) |
fusidic acid free acid - Reference Information
| LogP | 2.68-6.75 at 20℃ |
| fusiform antibiotics | fusidic acid is also known as fusiform acid, Brown mold sodium, furomycin, or stiromycin, is a fusicyclosporine antibiotic with a steroid skeleton, and its chemical structure is similar to that of cephalosporin P, not a hormone, it is produced by Fusobacterium coccineum or some Cephalosporium spp in fungi. The antibacterial spectrum is narrow, similar to novobiocin, but has a significant effect on Bacteroides fragilis and a weaker effect on streptococci spp, Pneumonia streptococci. Its mechanism of action is to inhibit bacterial protein synthesis, antibacterial or bactericidal effect. It has strong antibacterial effect on Staphylococcus (including methicillin resistant strains or other antibiotic resistant strains), Streptococcus, Enterococcus, diphtheria, Clostridium, neisseria and Mycobacterium tuberculosis also have certain antibacterial effect, weak effect on Bacteroides fragilis. Gram-negative bacteria in addition to Neisseria gonorrhoeae, Neisseria meningitidis, Clostridium difficile, fragile Bacteroides and other sensitive to this product, the other are resistant to this product. In vitro, Staphylococcus is very easy to produce resistance to this product. There was no cross-resistance between this drug and other anti-infective drugs. fusidic acid is clinically used for osteomyelitis or skin and soft tissue infections caused by sensitive bacteria. It is also used for other antibiotics treatment failure of deep infection, such as sepsis, Pneumonia, endocarditis, etc. Adults: oral, once 500mg,tid; Severe double. Local administration, bid ~ tid, applied to the affected area, treatment for 7 days. Treatment of scabies can be based on the need to extend the course of treatment. Children: oral, for children under 1 year old, 50mg/kg daily, three times; For children aged 1 to 5 years old, 250mg once, tid; For children aged 5 to 12 years old, usage and dosage with adult. |
| sodium fusidate | , it is a narrow-spectrum antibiotic with a steroidal skeleton, which is a derivative of fusidic acid, white crystal or crystalline powder, odorless, bitter, slightly hygroscopic, soluble in water and ethanol, slightly soluble in chloroform, insoluble in copper, ether, benzene. It is successfully developed for the first time by Leo pharmaceutical company of Denmark, and its trade name is ristin. This product has strong tissue penetration, mainly metabolized in the liver, and excreted by bile, almost not excreted by the kidney, with low toxicity, by inhibiting bacterial protein synthesis to produce bactericidal effect, it has good antibacterial effect on Gram-positive bacteria and good drug resistance. At the same time, strains resistant to penicillin, methicillin and other antibiotics are still sensitive to this product, there was no cross-resistance between sodium fusidate and other antibiotics used clinically. This product is a non-cephalosporin antibiotic, so it does not need to do skin allergy test. At present, it has been widely used in clinical treatment of various infections caused by various sensitive bacteria, especially Staphylococcus, such as osteomyelitis, septicemia and endocarditis, recurrent infections of cystic fibrosis, bacterial endocarditis, Pneumonia, meningitis, diphtheria, tuberculosis, skin and soft tissue infections, Surgical and traumatic infection, etc. Intravenous administration is indicated for severe infections or infections with drug-resistant strains, as well as for MRSA infections. But because of its easy to produce drug resistance, more as an adjuvant drug. Oral treatment of Clostridium difficile-induced pseudomembranous colitis has good effect.|
| pharmacokinetics | sodium fusidate has excellent tissue permeability and is widely distributed in the body. It is particularly important clinically that the product not only has a high concentration in tissues with abundant blood supply, but also has a high concentration even in tissues with less vascular distribution. Known in pus, sputum, soft tissue, heart, bone tissue, synovial fluid, dead bone pieces, burn scabs, brain abscesses, and intraocular, the concentration of sodium fusidate exceeded its minimum inhibitory concentration against Staphylococcus (0.03~0.16 μg/ml). Sodium fusidate is metabolized in the liver and excreted mainly by bile and almost not by the kidneys. This product is very low toxicity, and clinical use of other antimicrobial drugs without cross-allergy, so it can be used for the treatment of patients with other antibiotic contraindications, such as allergic to penicillin or other antibiotics. Sodium fusidate is recommended to be used in combination with other anti-staphylococcal agents to reduce the development of resistance when prolonged use is required due to severe or deep infection. Sodium fusidate can be used in combination with penicillinase-resistant penicillins, cephalosporins, erythromycin, aminoglycosides, lincomycin, rifampicin or vancomycin, and additive or synergistic effects can be obtained. |
| biological activity | Fusidic acid (Fusidate),Fusidium coccineum is a steroidal antibacterial antibiotic, without corticosteroid effect. Fusidic acid inhibits bacterial growth by preventing ribosomes from releasing translation elongation factor G (EF-G). |
| Target | Bacterial |
| Use | in clinical application, sodium salt is usually prepared, and the molecular formula of sodium salt is C31H47NaO6. Fusidic acid is highly sensitive to various Gram-positive cocci associated with skin infections, especially to staphylococci, is also effective against resistant Staphylococcus aureus, and also has some antibacterial effect against some Gram-negative bacteria. No cross-resistance to other antibiotics |
Last Update：2024-04-09 20:49:11
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